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Press Release 09-149

Uncovering the Secrets of Ulcer-causing Bacteria

Clever biochemical strategy enables bacteria to move freely and colonize host

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Illustration showing H. pylori liquefying stomach mucin to cross over to the epithelial cells.

Contact with stomach acid keeps the mucin lining the epithelial cell layer in a spongy gel-like state. This consistency is impermeable to the bacterium Heliobacter pylori. However, the bacterium releases urease which neutralizes the stomach acid. This causes the mucin to liquefy, and the bacterium can swim right through it.

Credit: Zina Deretsky, National Science Foundation


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H. pylori bacterium stuck in a mucin gel at pH4. The flagella rotate but the bacterium does not move freely. But it gains motility as it increases the pH level of the mucin.

Credit: Jonathan Celli, Boston University

 

This video clip shows H. pylori bacteria moving around in a mucin solution at pH 6. The higher pH level means the mucin is less solid and allows greater movement for the bacteria.

Credit: Jonathan Celli, Boston University