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Discovery
New Gene Sequencing Method Could Reduce Cost, Increase Speed

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Illustration of a double-stranded DNA in a synthetic nanopore revealed by molecular simulation.

Physicists at the University of Illinois Urbana-Champaign are working to develop a new method to sequence the human genome that will make the dream of the $1,000 genome a reality. Here, double-stranded DNA in a synthetic nanopore revealed by molecular simulation.

Credit: Aleksei Aksimentiev, University of Illinois at Urbana-Champaign


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This movie illustrates electric field-driven transport of double-stranded DNA through a synthetic nanopore obtained as a result of a large-scale molecular dynamics simulation. The DNA molecule stretches as it permeates through the pore constriction, tilting its bases, and that enables researchers to detect sequences.

Credit: Aleksei Aksimentiev, University of Illinois at Urbana-Champaign

 

This movie illustrates the imaging capability of a high-performance computer system that, in this case, provides atomic-resolution description of DNA transport through a synthetic nanopore.

Credit: Aleksei Aksimentiev, University of Illinois at Urbana-Champaign

 



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