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A hidden pocket within a vital HIV protein can be targeted by drugs that act as "molecular wedges."
A hidden pocket buried within a vital HIV protein (Reverse Transcriptase) can be targeted by drugs that act as "molecular wedges" and effectively prevent replication of the virus.
Credit: Anthony Ivetac, Sara E. Swift and J. Andrew McCammon, Department of Chemistry and Biochemistry, University of California at San Diego; John Naughton, Arturo Diaz and John A. T. Young, The Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies; Paul L. Boyer and Stephen H. Hughes, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute
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