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News From the Field

Gene responsible for hereditary cancer syndrome found to disrupt critical growth-regulating pathway


November 7, 2013

the gene FLCN Whitehead Institute scientists have reported that the gene mutated in the rare hereditary disorder known as Birt-Hogg- Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway. This is an unexpected finding, as some cancers keep this pathway turned on to fuel their unchecked growth and expansion.  Full Story

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Whitehead Institute for Biomedical Research

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