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News From the Field

The Key to Unlocking the Secret of Highly Specific DNAzyme Catalysis


November 12, 2007

Yi Lu, Taekjip Ha and Hee-Kyung Kim Using an extremely sensitive measurement technique, researchers at the University of Illinois have found clear evidence that a lead-specific DNAzyme uses the "lock and key" reaction mechanism. In the presence of zinc or magnesium, however, the same DNAzyme uses the "induced fit" reaction mechanism, similar to that used by ribozymes. Full Story

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University of Illinois at Urbana-Champaign

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