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Designing Synthetic Cells and Cellular Components (Designer Cells)

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NSF 24-539

NSF's implementation of the revised 2 CFR

NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website. These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.

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All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

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Synopsis

Designer Cells seeks projects that use the tools of synthetic biology to better understand how the systems and components of cells are built. This includes what is required for the components and systems to function properly, and to explore molecular and cellular diversity beyond what exists in nature.

The synthetic cell components or systems that may be generated and analyzed include ribosomes, mitochondria, membranes, regulatory modules, sensory systems, and molecular machines. These may be integrated into synthetic cells or cell-like systems, and they may be designed with novel molecular building blocks to study the design spaces evolution has not sampled or selected.

Projects that aim to identify systems or components that are required for cells to function properly, or those that are dispensable, by generating stripped-down or minimal versions of cells, are welcome.   

All projects submitted in this research area should include a consideration of the risks and benefits of the research and other relevant societal implications.

Program contacts

Name Email Phone Organization
Anthony G. Garza
aggarza@nsf.gov (703) 292-8440 BIO/MCB

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