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This program has been archived.

Division of Environmental Biology

Macrosystems Biology and NEON-Enabled Science  (MSB-NES)

Transitioning funding for macrosystems biology and NEON-enabled science

Over the last 13 years since the creation of the Macrosystems Biology and NEON-Enabled Science (MSB-NES) program began, the field of macrosystems biology has grown in size and recognition and has pioneered technical and conceptual advances to study processes that intrinsically play out at large spatial scales with significant relevance to a variety of areas in environmental and biological science.

Additionally, NSF’s National Ecological Observatory Network (NEON) has now been in operation for several years and is producing resources, data, and assignable assets used broadly across the biological sciences community. Over 500 publications already cite the use of NEON data.

As such, these areas have outgrown the need for a special call for proposals to highlight NSF’s support for them. Therefore, the MSB-NES program will "graduate" after awards made in Fiscal Year 2024, the deadline for proposals having just passed. This means that there will be no funding for new awards by the program in Fiscal Year 2025, but support for macrosystems biology and biological research supported by NEON data will expand through other programs.

Where to submit macrosystems biology and/or NEON-enabled science proposals moving forward
NSF will continue to support macrosystems biology and NEON-enabled science through programs including Core Programs within the Division of Environmental Biology (DEB), the Integrative Research in Biology (IntBIO) Track in Core Programs across the Directorate for Biological Sciences, infrastructure programs, workforce development efforts, and programs aimed at supporting interdisciplinary biology.

Researchers wishing to conduct macrosystems biology or NEON-enabled science can send proposals to these programs and/or discuss their project ideas with NSF Program Directors prior to proposal submission.

As a reminder, BIO Core Programs (including the Innovation, Capacity, and Sustaining programs in the Division of Biological Infrastructure (DBI)) accept proposals at any time.

Division of Environmental Biology (DEB)

Division of Biological Infrastructure (DBI)

Biology Integration Institutes (BII)
Biodiversity on a Changing Planet (BoCP)
Organismal Response to Climate Change (ORCC)

Proposals using NEON data and/or resources* to advance an area of biology may also be applicable to the following programs, depending on the area of biology on which they focus.

Division of Integrative Organismal Systems (IOS)

Division of Molecular and Cellular Biosciences (MCB)

* Proposals that plan to use NEON resources that are not generally available in the public NEON data catalogue, such as NEON assignable assets, on-site sampling or experiments, access to specimens or samples, or other work outside the standard, available NEON data must include a letter of collaboration from the NEON Project management organization that attests to the anticipated availability of the resources. See for further instructions on obtaining this letter.

NEON Related RCNs

The program continues to welcome proposals for Research Coordination Networks (RCNs) driving convergent science with the National Ecological Observatory Network (NEON). Please see for more information.

Name Email Phone Room
Matthew  D. Kane (703) 292-7186   
Catherine  O'Reilly (703) 292-7934   
Kari  Segraves (703) 292-8935   
Jason  B. West (703) 292-7410   


Solicitation  22-504

Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 22-1), is effective for proposals submitted, or due, on or after October 4, 2021. Please be advised that, depending on the specified due date, the guidelines contained in NSF 22-1 may apply to proposals submitted in response to this funding opportunity.




The Macrosystems Biology and NEON-Enabled Science (MSB-NES): Research on Biological Systems at Regional to Continental Scales program will support quantitative, interdisciplinary, systems-oriented research on biosphere processes and their complex interactions with climate, land use, and changes in species distribution at regional to continental scales as well as training activities to broaden participation of researchers in Macrosystems Biology and NEON-Enabled Science.

MSB-NES projects that use data and/or resources from the National Ecological Observatory Network (NEON) are encouraged. Substantive NEON-enabled projects rely on data and/or samples collected by NEON and/or co-locate research activities at NEON sites. Projects may develop tools that will explicitly enhance the processing, use, and/or analysis of NEON data or collections, in the context of addressing a specific research question or hypothesis. However, proposals primarily focused on tool development that can be used for a broad class of research questions or for topics that meet the needs of a community of researchers should be directed toward the Infrastructure Innovation for Biological Research (Innovation) or Infrastructure Capacity for Biological Research (Capacity) programs in the Division of Biological Infrastructure.

What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)

Map of Recent Awards Made Through This Program