Genetic Mechanisms

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 Apply to NSF 13 -510

The cluster supports inventive studies seeking to address the fundamental questions of how genes work, how genes are maintained and inherited, and how genes and genomes change.  Theoretical and experimental research is welcome that integrates structural, biochemical, genetic, and "omic" (genome, transcriptome, interactome, phenome, etc.) data to understand the mechanistic relationship of genotype to molecular phenotype. Of particular interest are research projects aimed at discovering integrated mechanisms coordinating processes that have traditionally been studied as discrete steps in gene expression, for example, chromatin modification, replication, transcription, RNA splicing/processing/degradation, and translation.  When driven by compelling questions, development and use of innovative in vivo and in vitro approaches, as well as research at the interfaces of genetics and other disciplines, are encouraged. 

Funding priority is given to proposals that promise high-impact contributions and significant advances in the following areas:

• Gene expression, including epigenetics and RNA-mediated regulation
• Chromosome dynamics, DNA replication, repair, recombination and inheritance
• Evolution of genes and genomes

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