Software Infrastructure for Sustained Innovation (SI2)

NSF's implementation of the revised 2 CFR

NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website. These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.

Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Updates to NSF Research Security Policies

On July 10, 2025, NSF issued an Important Notice providing updates to the agency's research security policies, including a research security training requirement, Malign Foreign Talent Recruitment Program annual certification requirement, prohibition on Confucius institutes and an updated FFDR reporting and submission timeline.

Grand Challenges in the Chemical Sciences

Synopsis

Software is an integral enabler of computation, experiment and theory and a primary modality for realizing the NSF's vision for a Cyberinfrastructure Framework for 21^stCentury Science and Engineering (CIF21) (http://www.nsf.gov/cif21). Scientific discovery and innovation are advancing along fundamentally new pathways opened by the development of increasingly sophisticated software. Software is also directly responsible for increased scientific productivity and significant enhancement of researchers' capabilities. In order to nurture, accelerate and sustain this critical mode of scientific progress, NSF established the multi-tiered Software Infrastructure for Sustained Innovation (SI²) program, with the overarching goal of transforming innovations in research and education into sustained software resources that are an integral part of the cyberinfrastructure.

Grand challenges in the chemical sciences will be advanced through the provision of enabling and sustainable software that allows researchers to flexibly and rapidly prototype and test new algorithms or methods; leverage new heterogeneous architectures; and explore new data-enabled scenarios. The NSF seeks to encourage collaborative software activities with foreign investigators which advance software innovation, capabilities, support and sustainability. This SI² solicitation is for international software collaborations addressing grand challenges in the chemical sciences, in partnership with the EPSRC in the United Kingdom.

Program contacts

Name	Email	Phone	Organization
Evelyn Goldfield Program Director, MPS/CHE	egoldfie@nsf.gov	(703) 292-2173	MPS/CHE
Gabrielle Allen Program Director, OD/OCI	gdallen@nsf.gov	(703) 292-2598	OD/OCI
Daniel S. Katz Program Director, OD/OCI	dkatz@nsf.gov	(703) 292-2254	CISE/OAC
Bruce Johnson Program Director, MPS/CHE	brjohnso@nsf.gov	(703) 292-2698	MPS/CHE
Sharon Neal Program Director, MPS/CHE	shneal@nsf.gov	(703) 292-4952	MPS/CHE

Awards made through this program

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Map of recent awards made through this program

Program status: Archived

Program 12-576 was archived.

Program guidelines

Previous guidelines NSF 12-576

Published:

June 28, 2012

Software Infrastructure for Sustained Innovation (SI2)

Status: Archived

Archived funding opportunity

NSF's implementation of the revised 2 CFR

Important information for proposers

Updates to NSF Research Security Policies

Synopsis

Program contacts

Awards made through this program

Software Infrastructure for Sustained Innovation (SI2)

Status: Archived

Archived funding opportunity

NSF's implementation of the revised 2 CFR

Important information for proposers

Updates to NSF Research Security Policies

Synopsis

Program contacts

Additional program resources

Awards made through this program

Related programs

Organization(s)