Colorful artistic illustration of artificial photosynthesis process

MPS Chemistry

The U.S. National Science Foundation Directorate for Mathematical and Physical Sciences (NSF MPS) supports multiple research programs in chemistry. These programs support fundamental discovery, invention and innovation conducted by a large and vibrant research community spanning all U.S. regions.

Research projects supported by these programs are essential for the discovery and development of innovations and technologies that grow the U.S. economy, strengthen national security and improve quality of life.

This research creates a strong scientific foundation for future technologies and the chemical industry, which is central to the U.S. economy and our daily lives. According to the International Trade Administration, the chemical industry converts raw materials like oil, natural gas, water, metals and minerals into more than 70,000 different products, from agricultural fertilizers and plastics to batteries and pharmaceuticals.

NSF MPS programs also play a critical role in training students and early-career researchers across the U.S. who will become the next generation of chemical scientists, engineers, educators and technicians.

Chemistry research programs

MPS invests in experimental and theoretical research across an array of chemistry research programs. The programs support individual researchers, small teams and interdisciplinary research spanning multiple programs.


Chemical Catalysis

Supports experimental and computational research directed towards the fundamental chemistry aspects of catalytic processes at the molecular and/or bond level of understanding.

Chemical Measurement and Imaging

Supports research and development of new measurement and chemical imaging tools that identify and quantify chemical substances, their properties and processes.

Chemical Mechanism, Function and Properties

Supports physical organic and physical inorganic chemistry research on the nature of chemical mechanism, function and structure property studies.

Chemical Structure and Dynamics

Supports experimental and applied computational physical chemistry research on the nature of chemical structure and bonding, electronic structure, and chemical dynamics.

Chemical Synthesis

Supports research that generates new fundamental knowledge and understanding of synthetic methodologies and the synthesis of complex and/or challenging chemical structures.

Chemical Theory, Models and Computational Methods

Supports the discovery and development of theoretical and computational methods or models to address a range of fundamental chemical challenges, with emphasis on emerging areas of chemical research.

Chemistry of Life Processes

Supports experimental and computational research that uses innovations in chemistry to study the molecular underpinnings of biological processes.

Environmental Chemical Sciences

Supports experimental and computational research in chemistry in order to understand environmental phenomena at the molecular scale.

Macromolecular, Supramolecular and Nanochemistry

Supports novel basic research that addresses fundamental questions and advances knowledge regarding the chemistry of macromolecular, supramolecular and nanoscopic structures. 

A chemist manipulates equipment in a fume hood lit with blue light.
A view from the top looking down on densely packed, atmospherically relevant, organic molecules

NSF Centers for Chemical Innovation

The NSF Centers for Chemical Innovation program supports research centers focused on major, long-term fundamental chemical research challenges. The centers conduct ambitious multidisciplinary research and are designed to seize rapidly emerging research opportunities related to national priorities.

Additional resources

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Preparing your proposal
A guide with helpful tips on how to write and submit a research proposal to NSF.